This study aims to determine the effects of grape seed and colchicine on pentadecafluorooctanoicacid (PFOA; Perfluorooctanoic acid) induced hepatic damage and on some serum biochemical parameters. A total of 60 Wistar albino rats (200-250 g) were divided into 6 equal groups. Those in group 1 (controls) received 0.9% saline weekly; group 2 PFOA twice a week; group 3 and 4 PFOA twice in the first week, followed by grape seed extract and colchicine for 4 weeks, respectively; group 5 and 6 received colchicine and grape seed extract for 4 weeks, respectively. Hyperemia, focal bleeding, fat degeneration and increase in connective tissue elements, pronounced in portal sites in particular, and infiltration of lymphoid series cell observed in the livers of the rats in group 2. Histological findings in the rats in group 3 and 4 were similar to those in group 2. Biochemically, there were no statistical differences between the control and experimental groups for serum total protein, albumin and globulin levels (P>0.05). Although total protein, albumin and globulin levels did not changed statistically (P>0.05) in group 3 and 4 compared to group 2, these parameters increased significantly for the rats allocated in the group 5 and 6 (P<0.01, P<0.05). Serum triglyceride and total cholesterol levels, and AST, ALT and ALP activities did not changed significantly (P>0.05). We conclude that grape seed extract and colchicine do not contribute to acute hepatic damage caused by PFOA shot.