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Curcumin is the yellow pigment in turmeric (Curcuma longa L) that is widely used as a spice, food coloring (curry) and preservative. Curcumin has a wide range of pharmacological properties including anti-inflammatory, antitumor promoter and anti-oxidant effects. In this study, the development and quantity of apoptosis in tumor tissue of solid Ehrlich Ascites Tumor model developed balb-c mouse by applying 100 mg/kg curcumin in different time periods were investigated. For this aim; 54 Balb-c female mice, constituted in vivo tumor by subcutaneous injection of 3x106 EAT cells, were divided into 3 experimental and 3 control groups. Using gavage method, 100 mg/kg curcumin dissolved in 9% alcohol was applied to experimental groups, 9% alcohol was applied to control groups in different time intervals. Long and short diameters measurement, and Terminal deoxyribonucleotidyl transferase-mediated dUTP-digoxigenin Nick End Labeling (TUNEL) and hematoxylin-eosin staining were applied to the extracted tumors of all groups and findings were supported with electron microscopic (TEM) evaluations. In long and short diameter measurement of acquired tumors, no significant differences were obtained (P>0.05). In microscopic evaluations different results were obtained from cell count of all groups. More apoptotic cells were determined in experimental group 2 (P<0.001) and 3 (P<0.05) than their control groups. According to statistical analysis, there was no significant difference between experimental group 1 that received longest-term curcumin and control 1 (P>0.05). Overall, the long-term 100 mg/kg applications of curcumin do not have any effect on apoptosis.