The case of esophageal stricture of a one-year-old queen that occurred after three anesthesia applications (one for ovariohysterectomy and the others for incisional wound complications) in two weeks was presented. Barium contrast esophagography provided the diagnosis of esophageal stricture located at the distal of thoracic esophagus, at the level of intercostal distance of 9-10 in mediastinum caudale. Feeding with canned food placed on a higher surface was recommended in order to prevent regurgitation and it was observed that regurgitation recovered in three days. Contrast radiography taken a month and a year later showed that location diagnosed as stricture was anatomically normal. In conclusion, repeated anesthesia performed with xylazine HCl and ketamine HCl in two weeks may contribute in developing esophageal stricture in cats and feeding with soft food from a higher surface may be preferred before any surgical treatment.