Acute phase proteins are plasma proteins which increase in concentration following infection, inflammation or trauma. In this study serum haptoglobin and ceruloplasmin levels were determined in dogs with various diseases in order to determine their potential value in the diagnosis and prognosis. Totally 97 dogs with various diseases and traumas, 2-7 years old, mixed breed and mixed sex were used in this study. According to the results of this study serum haptoglobin and ceruloplasmin concentrations in dogs with various diseases were changed to compare with the control group. The results of this study it seems that serum haptoglobin and ceruloplasmin levels are raised in dogs with variety of disease. As a result of this study it thought to be serum haptoglobin and ceruloplasmin levels should prove to be valuable diagnostic tool providing evidence of an inflammatory or infectious process.