Under intensive farming conditions, the poultry environment contains microorganisms that continuously challenge the bird's immune system. Disease challenge is only one of the many factors that will have an effect on the nutrient requirements of poultry. Insufficient nutrient consumption will reduce the effectiveness of the bird's defense mechanisms. Since the possibility of disease challenge is always present in today's poultry operations, the nutritionist must realize that the bird's metabolism and immune system are constantly adjusting to the stress of environment or disease and nutrient requirements may need to be increased at certain times. The aim of this article to review the effects of nutrients on immunity with data of recently published.