Tibial plateau leveling osteotomy (TPLO) is one of the tibial osteotomy techniques for canine cranial cruciate ligament rupture. The purpose of this study is to evaluate the clinically and radiologically findings of the patients with cranial cruciate ligament rupture treated by tibial plateau leveling osteotomy. In our clinical study, treatment of cranial cruciate ligament rupture in 18 dogs with a total of 20 stifles was performed. Cases were diagnosed with cranial cruciate ligament rupture, technical measurements for the operations are determined and the cases were prepared for the operation during the preoperative period of the clinical and radiological examinations. Following the operation, postoperative clinical and radiological evaluations were performed on the 10th, 30th, 60th, 90th and 120th days. At the end of the study, it was observed that the dogs retained stifle joint motion ability, early healing of the osteotomy side in the postoperative period, all stifle joint functions were retained after a period. It was determined that this method of operation can securely (in regards to joint stabilization) be performed on especially in large breed dogs.