Acta Veterinaria Eurasia
Original Article

Pharmacokinetics of Difloxacin in Probiotics-Treated Mycoplasma Gallisepticum Infected Chickens

1.

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

2.

Department of Biochemistry, Animal Health Research Institute, Dokki, Giza, Egypt

Acta Vet Eurasia 2022; 48: 87-93
DOI: 10.54614/actavet.2022.21054
Read: 173 Downloads: 111 Published: 19 April 2022

The impact of probiotics on difloxacin disposition in Mycoplasma gallisepticum-infected chickens after intravenous and oral administration (10 mg/kg) and its tissue residues after oral administration (10 mg/kg for 5 days) was studied. Difloxacin concentrations were estimated by the high-performance liquid chromatography method. Following intravenous administration of difloxacin, the volume of distribution in probiotic-pretreated Mycoplasma gallisepticum-infected chickens (4.05 ± 0.07) was less than that in non-treated birds (4.16 ± 0.07 mg/μg/mL). The t1/2β of difloxacin in probiotic-pretreated Mycoplasma gallisepticum-infected chickens (4.75 ± 0.09 hours) was significantly longer than that in the non-treated ones (4.55 ± 0.05 hours). The total body clearance of the drug from the plasma of probiotic-pretreated Mycoplasma gallisepticum-infected chickens (0.64 ± 0.00 mg/(μg/mL)/h) was less than that in non-treated ones (0.69 ± 0.01 mg/(μg/mL)/h). The area under the curve extrapolated to last plasma concentration0–t (15.20 ± 0.08 μg/mL/h) and the mean residence time (6.33 ± 0.11 hours) values in probiotic-pretreated Mycoplasma gallisepticum-infected chickens were larger than those in non-treated ones (14.13 ± 0.22 μg/mL/h and 6.02 ± 0.06 hours). The drug was rapidly absorbed orally in probiotic-pretreated Mycoplasma gallisepticum-infected chickens compared to non-treated ones (t1/2ab 1.47 ± 0.02 vs. 1.53 ± 0.05 hours). The peak serum concentration of difloxacin in probiotic-pretreated Mycoplasma gallisepticum-infected chickens was higher than that in non-treated ones (1.46 ± 0.07 vs. 1.18 ± 0.07 μg/mL) and was achieved at shorter time to peak concentration (2.59 ± 0.01 vs. 2.74 ± 0.05 hours). Residue levels of difloxacin were lower in probiotic- pretreated Mycoplasma gallisepticum-infected chickens than in non-treated ones in all examined tissues.

Cite this article as: Mohamed, A., Hassan Atta, A., Darwish, A., & Mohamed, H. F. (2022). Pharmacokinetics of Difloxacin in Probiotics-Treated Mycoplasma Gallisepticum infected Chickens. Acta Veterinaria Eurasia. 48(2), 87-93.

Files
ISSN 2618-639X EISSN 2619-905X