In this paper we analyze the response of bone tissue to a transosseous introduction of implants made of copper (Cu), medical steel 12X18H9T, steel with nitrides of titanium and hafnium coatings (TiN + HfN), as well as steel coated with titanium and zirconium nitrides (TiN + ZrN) into the diaphysis of the tibia of experimental rats. The obtained results showed that the restoration of the injured bone and bone marrow in groups with implants made of steel 12X18H9T occurred without the participation of the granulation and cartilaginous tissues, but with implants made of steel coated with titanium and hafnium nitrides (TiN + HfN), this bone recovery also took place in the early term. At the same time, in groups, where the implants were made of copper (Cu), implants were made of steel coated with titanium and zirconium nitrides (TiN + ZrN) were used, such phenomena as necrosis, lysis and destruction of the bone were registered and the bone tissue repair went through formation of the cartilaginous tissue.