Acta Veterinaria Eurasia
Research Article

Morphological and Functional Changes in Rat Brain under Total Sleep Deprivation

1.

Institute of Physiology n.a. A.I. Karayev, Azerbaijan National Academy of Sciences

2.

Yüzüncü Yil University, Faculty of Education, 65080 Van, Turkey

Acta Vet Eurasia 2015; 41: 138-142
DOI: 10.16988/iuvfd.2015.45988
Read: 813 Downloads: 395 Published: 23 December 2019

In this article the effect of 36 h total sleep deprivation (TSD) on behavioural reactions of rats (rearing, grooming and sexual activity) and on ultrastructure of brain neurons have been studied. A group of somnogenic structures (III-V layers of the frontal limbic cortex, CA1 area of the dorsal hippocampus, reticular formation of pons varolli, nucleus raphe dorsalis and locus coeruleus) of the brain of 6 month-old Wistar rats has been analized in this study. It has been revealed that dystrophic changes (chromatolysis of cytoplasm and vacuolization) enveloping a group of medium-sized neurons (20-30 (μ) micron in diameter) are accompanied by decrease of numbers of rearing, grooming and sexual activity. It is supposed that dystrophic changes revealed in medium-sized neurons result in partial disturbances of integrative and behavioral reactions of animals.

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