Zona pellucida (ZP) glycoproteins, due to their critical role in mammalian fertilization, have been used as immunogens in contraceptive vaccines. Immunocontraception using zona pellucida antigens, specifically porcine zona pellucida (pZP), has become one of the most promising reproducitive control tools in the world today. This reviews describes the importance and features of contraceptive vaccine with zona pellucida glycoproteins, with data of recently studies.