Evaluation of Some Antioxidant Enzymes in Cattle Infected with Foot and Mouth Virus

The present study was conducted to evaluate the activities of superoxide dismutase, glutathione peroxidase, malondialdehyde, catalase and their correlation in cattle infected with foot and mouth virus (FMD). Forty cows were diagnosed and confirmed for FMD. Ten clinically healthy adult cattle were selected as control. Superoxide dismutase (SOD) glutathione peroxidase (GPx), malondialdehyde (MDA) and catalase (CAT) were measured by validated standard methods. SOD and GPx were significantly lower in the infected animals compared with the healthy group (P<0.05 in all cases). The mean concentration of malondialdehyde (MDA) was significantly higher in infected animals compared with healthy cows (P<0.05). There were no significant differences between the mean activities of catalase in control group compared with infected group. There were significant associations between (GPx) and catalase (CAT) in the control group. In the FMD group, significant associations were observed for MDA with catalase. The results of this study revealed that SOD, GPx decreased and MDA increased in FMD-infected cattle in response to viral infection. However, in the future more detailed future studies are required to characterize such responses and to improve the development of novel control strategies against FMD.