DOI: 10.26650/actavet.2019.434600Studying the effect of general anaesthesia onblood parameters is extremely important both in terms of patient safety anddetermining protocol suitability for the patient. There is no study on theassessment of the effects of Diazepam/Propofol and Diazepam/Remifentanilcombination administered to dogs on clotting time, thrombin time (TT),prothrombin time (PT), active partial thromboplastin time (aPTT) and buccalmucosa bleeding time (BMBT). The purpose of the study presented is toinvestigate the effects of Diazepam/Propofol and Diazepam/Remifentanilcombinations on coagulation parameters in dogs aged 5 years and older,requiring surgery for various reasons. Prior to anaesthesia (T0), it was foundthat there was no difference between the two groups in terms of PT, TT, aPTTand BMBT (p=0.426 p=0.091, p=0.166, p=0.686, p=0.209, respectively). Followinganaesthesia (T1), it was found that the buccal mucosal bleeding time in dogs inthe Diazepam/Remifentanil group had a tendency to be shorter (p=0.084) thanthose in the Diazepam/Propofol group. Also, PT in the Diazepam/Remifentanilgroup was longer (p=0.031) compared to the Diazepam/Propofol group. Nosignificant difference was found between the groups with respect to clottingtime, TT or aPTT (p=0.191, p=0.467, p=0.972). While it is stated that neuroleptanalgesiaproduces reliable anaesthesia induction in unwell patients, based on the dataobtained at the end of the study, it was determined that Diazepam/Propofolcombination is more reliable in the anaesthesia of patients requiring surgicalintervention.