Acta Veterinaria Eurasia
Short Communication

A Preliminary Study of Evaluation of the Role of Interleukin-1β (IL-1β) and Effects on Post-Treatment in Goats Experimentally Induced for Mannheimiosis


Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengkalan Chepa, Kelantan, Malaysia


Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Malaysia

Acta Vet Eurasia 2023; 49: 55-57
DOI: 10.5152/actavet.2022.22043
Read: 723 Downloads: 278 Published: 24 October 2022

Pro-inflammatory cytokines are necessary for an inflammatory response to infection or tissue injury. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine involved in the pathophysiology of acute lung damage and respiratory distress syndrome. The study aims to evaluate the effect of treatments on the levels of IL-1β in goats induced with Mannheimiosis. Twenty male goats were divided into five groups (n = 4). All groups except group 1 (negative control) were inoculated intranasally with Mannheimia haemolytica (107 CFU/mL). Goats in group 2 served as positive control. Goats in groups 3 and 4 were treated with an antimicrobial (oxytetracycline, SID) on days 6 and 9 of post-infection and an anti-inflammatory drug (Flunixin meglumine, BID) for 5 days of post-infection, respectively. Goats in group 5 received both treatments. Blood samples were collected via jugular vein at 24 hours, days 5, 9, and 11 of post bacteria inoculation for interleukin-1β analysis. The levels of IL-1β within 24 hours and day 5 of inoculations were significantly increased (p < .05) in groups (2, 3, 4, 5) compared to the negative control. On days 9 and 11, the levels of IL-1β in groups 2 and 3 remained significantly higher (p < .05) than in other groups. These findings indicated a synergistic effect of antibiotic and anti-inflammatory drugs combination in reducing the levels of IL-1β in the blood in goats induced with Mannheimia haemolytica.

Cite this article as: Faahimaah Abdul Hamid, F., Farhan Hanif Reduan, M., Sabri, J., Firdaus Jesse Abdullah, F., Naji Odhah, M., Athirah Binti Abdul Manaf, N., Jefri Norsidin, M., Nor Che Yahya, S., Noor Aina Kamaruzaman, I., Rahman Aziz, A., & Zul Izzati Mohd Rajdi, N. (2022). A preliminary study of evaluation of the role of interleukin-1β (IL-1β) and effects on post-treatment in goats experimentally induced for Mannheimiosis. Acta Veterinaria Eurasia., 49(1), 55-57.

EISSN 2619-905X