Feline polycystic kidney disease (PKD) is an inherited autosomal dominant disease that has been identified in Persian cats and Persian related breeds such as the Exotic Shorthair cats. PKD has been reported sporadically in the veterinary literature and progress asymptomaticly until the renal deficiency is observed. Diagnosis of the PKD can be carried out by abdominal ultrasonography and DNA test in 7 weeks old. Our case was a 7 years old male Persian cat which had been brought to Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University with complaints such as weight loss, polydipsia, polyuria, lethargy and bilateral enlargement of abdomen. Although the body temperature and outline of the kidneys were normal in physical examination, the cat was lathergic and both of the kidneys was enlarged. At the result of ultrasonographic evaluation, the enlargement of the both kidneys were observed and numerous cysts were determined which were originated from both medulla and cortex of the kidneys and their diameters were changed between 2-15 mm. Although a medical therapy protocol had carried out for the purpose of increasing the quality of his life, the patient was died of 36th day of the treatment.